2017
Bayesian Joint Modelling of Longitudinal Data on Abstinence, Frequency and Intensity of Drinking in Alcoholism Trials
Buta E, O’Malley S, Gueorguieva R. Bayesian Joint Modelling of Longitudinal Data on Abstinence, Frequency and Intensity of Drinking in Alcoholism Trials. Journal Of The Royal Statistical Society Series A (Statistics In Society) 2017, 181: 869-888. PMID: 31123390, PMCID: PMC6527419, DOI: 10.1111/rssa.12334.Peer-Reviewed Original ResearchBayesian joint modellingParameter estimate biasStandard frequentist approachRandom effectsLog-normal modelJoint modelFrequentist approachBayesian approachMean squared errorJoint modellingEstimate biasIntensity of drinkingSimulation studyFrequency of drinkingSeparate modellingModellingLongitudinal outcomesClinical trialsSame subjectsSustained abstinenceModelLogistic partAbstinence
2015
Reduction of alcohol drinking in young adults by naltrexone: a double-blind, placebo-controlled, randomized clinical trial of efficacy and safety.
O'Malley SS, Corbin WR, Leeman RF, DeMartini KS, Fucito LM, Ikomi J, Romano DM, Wu R, Toll BA, Sher KJ, Gueorguieva R, Kranzler HR. Reduction of alcohol drinking in young adults by naltrexone: a double-blind, placebo-controlled, randomized clinical trial of efficacy and safety. The Journal Of Clinical Psychiatry 2015, 76: e207-13. PMID: 25742208, PMCID: PMC4442987, DOI: 10.4088/jcp.13m08934.Peer-Reviewed Original ResearchConceptsHeavy drinking daysBlood alcohol concentrationPercent days abstinentDrinking daysNumber of drinksYoung adultsDays abstinentPercent heavy drinking daysOutpatient research centerSafety of naltrexonePlacebo-controlled studySerious adverse eventsRisk-benefit ratioPercentage of daysAdverse eventsSecondary outcomesPrimary outcomeFrequency of drinkingOpioid antagonistAdult heavy drinkersAlcohol drinkingClinical trialsEvaluable samplesYoung adult heavy drinkersTreatment period
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